AD8421 10MHz Instrumentation Amplifier: Low-Noise Precision for High-Speed Signal Chains

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Published: 12 February 2026 | Last Updated: 12 February 2026

9

AD8421TRMZ-EP-R7

AD8421TRMZ-EP-R7

Analog Devices Inc.

65mA per Channel 1nA 94 dB Instrumentational OP Amps 5V~36V ±2.5V~18V AD8421 8 Pins 8-TSSOP, 8-MSOP (0.118, 3.00mm Width)

Purchase Guide

65mA per Channel 1nA 94 dB Instrumentational OP Amps 5V~36V ±2.5V~18V AD8421 8 Pins 8-TSSOP, 8-MSOP (0.118, 3.00mm Width)

Optimize your signal chain with the AD8421 Instrumentation Amplifier. Features 3.2nV/√Hz noise and 10MHz bandwidth. Ideal for medical and vibration analysis. Buy now!

Executive Summary: What is the AD8421?

The AD8421 is a high-speed, low-power instrumentation amplifier (In-Amp) designed by Analog Devices for precision signal conditioning where low noise and high bandwidth are critical. It serves as a high-performance bridge between low-level sensor signals and high-speed analog-to-digital converters (ADCs).

  • Market Position: High-performance precision amplifier; balances extreme speed with ultralow noise.

  • Top Features: 10 MHz bandwidth (G=1), 3.2 nV/√Hz input voltage noise, and 35 V/µs slew rate.

  • Primary Audience: Ideal for medical device designers, vibration analysis engineers, and high-end audio equipment manufacturers.

  • Supply Status: Active (Widely available for new designs).


1. Technical Specifications & Performance Analysis

The AD8421 stands out in the Analog Devices portfolio by breaking the traditional trade-off between power consumption and speed.

1.1 Core Architecture

The AD8421 utilizes a classic 3-op-amp architecture but is optimized for high-speed performance. Unlike traditional In-Amps that struggle with bandwidth at high gain, the AD8421 maintains significant speed across its gain range, making it suitable for multiplexed systems where fast settling time is required.

1.2 Key Electrical Characteristics

For engineers managing a strict power budget or high-precision requirements, the following specs are critical: 

- Input Voltage Noise: Only 3.2 nV/√Hz at 1 kHz, ensuring that the amplifier does not mask low-level signals. 

- High Speed: A 10 MHz bandwidth (at G=1) and a 35 V/µs slew rate allow the part to handle fast transients and high-frequency AC signals. 

- Low Power: Despite its speed, it consumes a maximum of only 2.3 mA, making it viable for high-density boards. 

- Input Protection: The device is robust, with inputs protected up to 40 V from the opposite supply rail, reducing the need for external clamping diodes.

1.3 Interfaces and Connectivity

The AD8421 is an analog-in, analog-out component. It interfaces seamlessly with: 

- High-Resolution ADCs: Its fast settling time makes it an ideal driver for SAR and Delta-Sigma ADCs. 

- Bipolar Supplies: Operates on ±2.5 V to ±18 V, providing flexibility for industrial or battery-powered rails.

2. Pinout, Package, and Configuration

Understanding the physical layout is the first step toward a successful PCB design.

2.1 Pin Configuration Guide

AD8421-AD8421-pinout_817e8bda_d3c0.jpg

The AD8421 typically uses an industry-standard 8-lead configuration: 

- -IN / +IN: Differential inputs for the sensor signal. 

- RG (Pins 1 & 8): Gain setting pins. A single external resistor sets the gain from 1 to 10,000. 

- REF: Reference pin; defines the output voltage level for a zero differential input. 

- V+ / V-: Power supply pins. 

- OUT: The amplified output signal.

2.2 Naming Convention & Ordering Codes

When ordering, look for suffixes like AD8421ARMZ (MSOP package) or AD8421ARZ (SOIC package). The "R" usually denotes the temperature range (-40°C to +85°C), and "Z" indicates RoHS compliance.

2.3 Available Packages

Package TypeDimensionsCommon Use Case
8-Lead SOIC4.9mm x 3.9mmGeneral purpose, easy prototyping/hand-soldering.
8-Lead MSOP3.0mm x 3.0mmSpace-constrained medical or portable devices.

3. Design & Integration Guide (For Engineers & Makers)

Pro Tip: Always place a 0.1µF ceramic capacitor as close as possible to the supply pins to minimize high-frequency noise.

3.1 Hardware Implementation

  • Bypass Capacitors: Use a combination of 10µF tantalum and 0.1µF ceramic capacitors to ensure stability.

  • PCB Layout: Keep the traces to the gain resistor (Rg) as short as possible. Any parasitic capacitance or inductance in the Rg loop will degrade the Common-Mode Rejection Ratio (CMRR) and introduce noise.

3.2 Common Design Challenges

  • Issue: Noise Coupling in Rg Loop: Users often see noise spikes when using a MUX.

  • Fix: Minimize the loop area between the RG pins and the resistor. If using a MUX to switch gains, place it physically adjacent to the AD8421.

  • Issue: Simulation Gain Errors: LTspice models may fail if the input common-mode voltage is floating.

  • Fix: Ensure your simulation schematic provides a DC path to ground for the inputs.

  • Issue: Output Saturation: Floating sources (like a battery) can cause the output to drift to the rails.

  • Fix: Install 10MΩ resistors from each input to ground to provide a bias current return path.

4. Typical Applications & Use Cases

📺 Recommended Video Tutorial:

👉 Click to Watch "AD8421" Guide on YouTube

4.1 Real-World Example: Vibration Analysis

In industrial predictive maintenance, piezoelectric accelerometers generate high-frequency, low-voltage signals. The AD8421’s 10 MHz bandwidth allows it to capture high-frequency harmonics of machine vibration, while its low noise ensures that the subtle "signature" of a failing bearing isn't lost in the background hiss.

5. Alternatives and Cross-Reference Guide

If the AD8421 is unavailable or doesn't perfectly fit your BOM, consider these alternatives:

  • Texas Instruments INA849: A direct competitor offering even lower noise (1 nV/√Hz) but potentially higher power consumption.

  • Texas Instruments INA821: A good alternative for lower-speed applications where cost-efficiency is prioritized over bandwidth.

  • Texas Instruments INA118: A legacy alternative; use this only if you are maintaining an older design, as the AD8421 outperforms it in almost every precision metric.

6. Frequently Asked Questions (FAQ)

Q: What is the difference between AD8421 and INA118?A: The AD8421 is significantly faster (10 MHz vs 800 kHz) and has lower noise, making it a modern upgrade for high-speed signal conditioning.

Q: Can AD8421 be used in Automotive applications?A: While it has robust input protection, check for AEC-Q100 qualification specifically if the design is for under-the-hood automotive use.

Q: Where can I find the datasheet and library files for AD8421?A: Datasheets are available on the Analog Devices website. Symbols and footprints can be found on UltraLibrarian or SnapEDA for Altium, KiCad, and Eagle.

Q: Is AD8421 suitable for battery-operated devices?A: Yes. With a maximum supply current of 2.3 mA, it is highly efficient for the level of speed and precision it provides.

7. Resources

  • Evaluation Boards: EVAL-INAMP-82RZ for quick SOIC prototyping.

  • Software: Use ADIsimDesign or LTspice for circuit simulation and stability analysis.


Specifications

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Datasheet PDF

Download datasheets and manufacturer documentation for Analog Devices Inc. AD8421TRMZ-EP-R7.
AD8421TRMZ-EP-R7

Analog Devices Inc.

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